Do you say something when you notice that a fellow jelly has been a little off?

I have noticed a particular jelly that is normally very sweet is currently much more combative. Since I spend most of my time on Fluther reading rather than interacting, I haven’t really interacted much with this jelly. Thus, I don’t feel like it is my place to approach the person about it, but the shift in behavior has me concerned that something is wrong. While I don’t interact as much as many people, the amount of time I spend reading makes me get to know and care about the people that do respond more consistently. So, I care about and am worried for this person, but if I were to express my concern, it would be coming from a stranger.

What about you? When you notice that someone is not themselves, how do you respond? Do you let it go because they wouldn’t recognize you if you tried, or do you send them a PM to let them know you care? What other ways do you respond when you notice someone is a bit off their normal game?