[nsfw] If Henry Winkler developed HIV would you call it AYYYDS (see details)?

Steve Urkel with irritable bowel syndrome. Did I do that?

Mine wasn’t exactly a pun. Sorry.

O.K. I’ll play, though I don’t know if you want a pun on an actor’s name, as you say in your details, or famous line, like in the question itself… I’m going with the latter so…

Jack Nicholson – Heeeere’s jaundice!

It’s the best I’ve got right now!

And @bkcunningham no, that wasn’t actually a pun, but it was worth it, just to see you mention Steve Urkel and irritable bowel syndrome in the same sentence. :-)

btw, Robin Gibb wasn’t so good at Stayin’ Alive.

Puns on names:

Lauren Bacolitis.

and

If he suffered from male pattern baldness, he might want to try Robert De Nirogaine.

Now I can’t stop.

Bluebird of Happiness Williams?

I missed that it was supposed to be an ailment. Laters.

If Danny De Vito’s wife was told she was dying through complications of an STD, would he say to her family, she’s soon to be gone-our-rhea?