A potential for negative consequences arising from any activity is always highly probable. “Out with the old, in with the new” is a maxim the young find easier to follow. Whatever what is gained in the transformation, something is lost. Change is inevitable, but it is also resented.
@Dr_Lawrence, the formation of a relationship affects existing relationships, some detrimentally.
Everything, mental and physical, is in a continuous state of transformation. Our bodies are made of atoms born in stars in galaxies long ago and far away. Mind or consciousness is linked in space and time to those moments of their births. However, this connection can only be realized with our body’s demise (imho).