Are all Tortoise Shell cats female?

Yep. Without a mutation (which would be very rare), male cats can’t have orange and black colors at the same time. So all Callicos are female too.

The only exception is when a male has XXY chromosomes, then you can get a calico male but he will be infertile.

No. I have known one (and only 1) male Tortoise Shell, which is enough to prove that they exist.

However, they are exceedingly rare, as it is a mutation.

As stated this is sex linked and an example of a Barr body process resulting in this phenomenon.

Yes, almost always, as are Calico. I have a Tortie Point Siamese. Dappled and speckled with cream and Sealpoint markings. She is adorable. Has the Sealpoint paws, ears and tail with cream and beige and chocolate mottling and an orange nose with blue eyes.

@Coloma Your “Kitteth” sounds adorable.
Please share a picture.
Thanks in advance….

@boffin Here she is ( Mia) in my avatar, isn;t she a funny little thing! I love her to bits!

And oddly enough for some reason [same reason?], orange cats are always male.

^ Not always, but something like 75% of the time. (I had a female orange cat growing up).

One of my friends has a female orange tabby cat.

@Coloma Thanks for sharing. She is adorable.