Do humans naturally and inevitably reject happiness, perfection, and all that is good?

In relation to something Agent Smith said in the 1999 film, The Matrix, “But I believe that, as a species, human beings define their reality through suffering and misery.”
Do you think that we can only live, can only accept life, if their is something bad, something to complain about, to cry and want to die over?
Is it and has it always been, in our nature to never truly rejoice in the beauty and simple goodness in life and love?
Will we always continue to sabotage every happy, loving relationship, every free, undeserved education, every meaningful, glorious life, every chance we get, any way we can?
Can you sit there, and accept that you do this? Can we admit to ourselves that we must make ourselves purposely suffer, purposely always see the bad over the good in any situation to accept living?
Drama queens, the suicidal, committment-phobes, anyone who is alive and unhappy…Why do they, do we, do this?
There are people out there, who have found their bliss, whose lives are fullfilling and lived to the very extent and beyond. So very few.
Why is it so DIFFICULT to be happy?