Do you think there's a distinction between the brain and the soul?

Lately, I’ve been thinking about this a lot. Your consciousness (aka your brain) is you and reality as you know it. Your soul, hypothetically, is the essence of you, the core of your being. It exists apart from your brain. But the way I see it, who you are is largely the sum of your genes (biological) and your experiences (stored in your brain). If your psychology creates your personality, then how can this be distinct from the soul? Can you be a good person with a bad soul, or vice versa? If so, why would God create “bad” souls? It seems strange to damn people from the start. How is it fair to condemn someone who is a bad person because of their brain chemistry?