Issues with my computer/mouse?

Last night while watching a tv show on my computer, an .avi file I’ve had for years if it matters, my computer froze, the sound stuttered and the image switched to a charming shade of blue death.

I restarted my computer and it wouldn’t boot halfway through. Tried again, and got stuck at a different point. Third time it worked, but now about 45 seconds in my mouse and keyboard will stop working. Not even long enough for me to log in to my username.

I was not connected to the internet at the time the error occurred. I haven’t used this computer in two weeks and before that it was perfectly fine.

I’m writing now from my laptop, but I have important school work on my desktop I need to pull off.

I’ve tried restarting it a bunch of times, unplugging unnecessary peripherals, etc. No dice.

Help!

It’s a three year old Dell, I forget the model – running Windows Vista Home Premium.

Oh, and I don’t have extra keyboards or another mouse to try – nor can I crack open the case tonight to get at my hard drive. I am lacking a proper screwdriver. I do know that the mouse and keyboard work fine when connected to my laptop though, so it’s definitely an issue with my pc. :)