What would have happened among Native Americans if the Europeans arrived 300 years later?

I get the feeling from my limited knowledge of history that the New World may have been a bit different if the Europeans arrived later.

The Aztec empire was fairly new when the Spanish arrived. Would they have been able to spread out further, carrying literacy along with them? Would they have been able to mount a strong resistance to the Europeans? In the northeast U.S., the Iroquois had become a fairly potent force. Would they have extended their influence? And what about the Cherokees in the southeast and the Comanches on the plains? How much longer could the Incas have gone on before picking up a written language?