How much does fatigue,weight gain,and depression play a part in the loss of sexual desire?

I’d say you have a perfect storm there. Each one individually can do it, so all three will almost certainly be an issue. Sexual interest being always high in males is a myth. But it can still be a problem in your relationship, especially if it was high before. The biggest issue I see is that removing one or two factors might not be enough.

Cymbalta might be doing it. Its side effects listed are weight gain, and decreased sex drive. You might want to talk to your doctor. But don’t expect miracles. Good luck.

To echo what charybdys said—yes, all of those things can have an impact, and they tend to all feed into each other as well. It might be hard to squeeze this in with your new, longer hours, but exercise could be helpful with all of those problems. And it sounds like it might be time for a med change? Talk to your doc—see if s/he has any good ideas. Good luck, and please do keep us posted.

All of those pieces can definitely add up and have a huge impact on your sexual interest. The only recommendation I can really offer is try another drug. Wellbutrin is one that seems to have the lower sexual side effects. Also, like nikipedia said, exercise can do a LOT for all aspects of your life. As tired as you feel, exercise absolutely will give you more energy (even though I knooooowww this is easier said than done).

Good luck!

Have you thought about talking to a therapist or someone similar so you have a place where you can vent all of your stress and work through some of these feelings? It might help you feel better if you can work out your emotions in a setting like that. They can also help you come up with ways to cope with stress/anxiety. Remember to take care of yourself and treat yourself well and don’t blame yourself for gaining the weight.

for me, i would say none of those things would effect my sexual desire, but to answer your question: 1. weight gain can lower self esteem. 2. fatigue can lessen desire to even engage 3, depression can go tandem with weight.

Yes, all those have a big impact on your sex drive – no doubt! And you really should address the depression before anything else.
Of the other issues, the weight is a particularly tricky one. I find it can have a negative impact when your shape/weight shifts in either direction. I’ve had times when I’ve been pretty out of shape and can’t even stand the thought of myself as being sexual at all, but then I’ve also had times when I’ve been in great shape and I worry about being perceived as too sexual and end up overcompensating.

Whatever you do, take small steps. A little more exercise, a call to find out
what therapy is available and recommended, an appointment with your doc
to adjust the meds, a few extra leaves of lettuce on the dinner plate, a minute a day of breathing without trying to solve anything. These are big changes when you’re carrying a lot of stress. Any of them is a good beginning. As was asking Fluther. Good for you. p. s. you sound very sexy to me.