I don’t know about extreme measures like lobotomy, but certainly sometimes limitations can provoke interesting states. For example, for a while I took to writing letters with my left hand, and I found that it really changed the quality of my writing.
Walter Murch, who does film editing, has this interesting process where he will take out what seems to be an essential component of the scene, in order to see how everything else present contributes. The analogy he uses is a naked “blue light bulb” that is placed to define the “blueness” of a scene. But if you unscrew and take out that harsh blue light, you start to see things which are authentically blue, and how they interact with each other.
As someone untalented in acting, I think the fact that I have to consciously and painstakingly work at my performance actually leads me to make connections that talented people cannot. (Admittedly, they have other advantages; but I love what I do, and right now I’m directing anyway…)
The truth is, I think most of those really talented people actually have to work hard too; even brilliant celloists have to practice; and the talent—or the technique—for hard work may actually be crucial in the success of the field you choose.