Besides the obvious, what are some other "Biggies" that are probably hateful, criminal and enemies to society?

Clearly, Big Oil, Big Pharma, Big Auto, etc are the usual targets of hatred or at least blame for everyone’s misfortune.

But I suppose it is possible that someday, all of those who hate these things will finally get their way, and oil and medicine and cars will disappear.

So what “Big” things are the up and comers. Who are the “Biggies” that are waiting in the wings, gradually working their way to a level of bigness that will make them worthy of popular disdain.