What are good examples of the "fish out of water" metaphor?

You know it, when a person ends up in a situation, whether by choice or circumstance and he or she finds herself dealing with things way above his head or she sticks out like a sore thumb amongst people better suited for that kind of place. Could you come up with examples of this same situation that has happened in real, still happening? Feel free to come up with funny or thought provoking examples as well. Thanks!

Also, as a suggestion, please incorporate the words “fish out of water” in your answers. Or maybe another saying of the same nature?

For example – “Lady Gaga is a fish out of water if she tries to enter the Our Lady of Mercy convent to be a nun.”