Has anybody had any experience with low dose naltrexone?

Treatment for what?

I have a liver disease autoimmune hepatitis cirrhosis of the liver decompensated liver failure. Transplant docs decided I have roughly a year before I need to be on the active list. After going and enrolling in the program meeting talking to patients doc financial people and social workers. After my experiences and reading and thought I have decided I don’t want transplant surgery. 90% sure anyway as I am having trouble grasping this on an emotional level.

What would be the mechanism by which the drug would reverse the liver disease?

What little I know, the drug for autoimmune diseases seems to fall into the category of too good to be true. So, I would be wary. If it were me I would want to investgate fully the possible negative side effects before trying it. Make sure liver damage isn’t one of the risks with the drug. Did you read the manufacturers insert? That would give you possible bad side effects. Have you talked to your doctor about it? I think one problem you might run into is it seems to me it is not commonly prescribed for your problem so it might be difficult to find a doctor who would prescribe it.

I understand being willing to try a drug even if it is not well tested for what is wrong with you. I have been in that sort of desperate situation. Mine was a bumpy road and just be careful. Listen to your body and your gut.

I have a hard time believing the disease could be reversed. Maybe at best stall it? I really don’t know much about your illness or that drug.

I hope you find a cure.

This might help.
http://www.sciencebasedmedicine.org/low-dose-naltrexone-bogus-or-cutting-edge-science/

Thanks everyone. I suppose I was looking for more accessible anecdotal evidence. But there seems to be a lot of that.

I was going to answer your question @Rarebear but you seemed to answer it yourself if you read the article and comments. I will for anyone else’s curiosity.
LDN dampens overstimulation of the branch of the immune system responsible for auto-immune activity while simultaneously increasing the functioning of the viral fighting branch by balancing the Th1-Th2 system.

In other words naltrexone is FDA approved for heroin addicts because it upregulates our endorphins, endorphin rush, anyone? Dr. Bihari’s theory was that autoimmune diseases are frequently seen in patients with an abnormally low endorphin level. In different people the disorder presents in different ways due to genetic expression life style etc. But by boosting endorphins supposedly we are now treating the cause and not the symptoms.

The side effects seem to be at least initially trouble sleeping at night and possible upset stomach. But this does not seem to a complete list. It may further damage the bodies ability to produce endorphins and may effect some some blood levels? Also not good for organ transplants as it boosts the immune system. Not enough research has been done though.

I thought maybe the UK had done more studies on this but I can’t seem to find any.

@Unbroken I know how Naltrexone works, thanks. My quesiton to you is how does upregulating endorphins affect liver disease? I don’t think it does.

That is the mystery. I have no idea. Truthfully my family thinks I should try it.

Better question: in my situation would you try it?

Absolutely not.

Thank you for your honesty