What could Trump DO that would cause even his supporters to bail out on him?

On another thread we were theorizing about who / what killed Epstein. A couple of folks (including me) think Trump had something to do with it. Epstein knew something about Trump that could destroy him.
What on earth could it be? Apparently the trash he’s actually done to date isn’t enough. Did he have sex with animals? Sex with other men? What would his base finally view as such deplorable behavior that they would actually quit him?