What medium(s) do modern cartoonists use?

I linked to this cartoon by Gary Larson in another thread and as an artist I was curious to know:

1. What medium did he use for this? I can see the ink but how about the color?

2. Are comic artists now using this medium or have they moved into digital- if so what program?

Feel free to post to samples and discuss this even if you are not quite sure yourself.