How to get kids to stop being so loud?

We have two boys ages 4 and 2. Sometimes they get so loud (screaming, screeching, yelling) I can hear my ear drums rattling. I’ve tried whispering to them to be quieter, I’ve tried raising my voice, I’ve tried time outs, I’ve tried trying to talk to them, taking them to a different part of the house etc… nothing seems to work. Do you have any sure fire ways to get them to not be so load?