How can I be a better shmoozer?

My job requires me to “work the room” at various banquets and ceremonies, start conversations with strangers, get people talking, etc., but I am not very good at small talk, and always feel uncomfortable in such situations. I am not at all nervous about walking up to someone and striking up a conversation, but I am often at a loss within a minute thereafter. I need advice from people who know how to shmooze. Any tips as to how to get people talking? How to move beyond small talk, and into meaningful or interesting conversation? Thanks.