Can I claim my home office on my taxes?

I work from home as an independent contractor for a small-ish business. At the end of the year I receive a 1099 rather than a W-2. I also own and manage a small retail rental property that I have to carry a business license for. Is that enough for me to deduct my home office and the expenses related to it from my taxes? (I already write off expenses for the rental property, but have never claimed the home office.)

If so, do you have any tips for me? Any pitfalls to watch out for?