What are some things I need to consider when starting my own comic?

I have this urge to make my own comic book. In middle school, I made my own monthly comic for a while based on people I knew, but it was all in pencil and only 5 pages or so.

For my new project, I’m thinking something more along the lines of Danger Girl, you know, ridiculously sexy women, action, near-nipple slips, zombies, off-panel sex, superevil enemies (like nazis), and cameos from a cool guy who looks like, I dunno, Harrison Ford.

What do I need to take into account when I make this comic? I don’t want a webcomic, but I doubt I’ll have the means to publish it on paper. I need advice on plot, characters, publishing, collaborating with others, anything you’ve got, I’ll take it.