What is the best configuration for data transfer between two external hard drives?

I often have to connect external hard drives via firewire to my mac and daisy chain them together because of lack of ports. If I want to transfer the fastest from hard drive A to hard drive B, what is the best configuration. Should hard drive A be hooked up to the computer and hard drive B be hooked up to hard drive A? Or should hard drive B be hooked up to the computer and hard drive A hooked up to hard drive B? Or does this not make any difference? Right now I’m transferring TBs of data so I want any advantage I can.