Isn't "mad science" actually "mad engineering"? Can you find me an example of "mad science" in popular media?

This is from a discussion a friend and I were having about this comic: http://imgur.com/Ebl0S.jpg
(by Sanjay Kulkarni, his website is currently down)

We were trying to come up with an example of actual science, e.g. hypothesis, control group, repeating an experiment, that sort of thing. Can the collective come up with any for me?