How could you handle annoying talkative person?

Suppose that someone you know is very very talkative, keep saying lots of stuff that don’t worth your while, repeating the topic again and again, keep saying stuff even though you’ve given the boring face, etc.

They’re your friends/family members, and you don’t want to hurt their feeling. You must also required to stay in the same room as them so running away isn’t a choice.

Any ideas other than punching their nose? (In your imagination).