When driving in your car, can you tell when something is not working right or about to break?

Sometimes while driving I get this vague feeling that something is not right with my truck; nothing I can pinpoint, just a warning that something is physically going wrong with the vehicle or the motor. I don’t obsess on how my truck is working or consciously tune into it each time I get in and start it up. So what are these subtle clues that I subconsciously pick up on? Which sense or senses are called into play? What do you notice yourself?