Is the Earth pretty much stuck with life from now on? Could it ever really all be gone?

Let’s assume there was an event, you name it, mega asteroid, world war, or a contagious epidemic… With all the bomb shelters, nooks and crannies on our planet where life happens to have a chance to be hiding and/or flourishing in secret do you think at least SOME life would survive and evolve over another million years?

As long as the earth is around (eg. not sucked into a black hole or enveloped by the sun) Could the earth really ever be devoid of all life?