From personal experience: Have you or a relative or friend been affected by perimenopause to a very dramatic extent?

I am referring to complete change of character, deep and dark thoughts, irritation beyond description, nerves, anxiety and anything else that may gobwith the territory? At what age and did the anti-depressant and anti-anxiety medication make a difference?

I have witnessed before my eyes a complete ball of nerves, a mess. Only 42 or so, looks healthy on the outside but geez the internal mess is tragic to see. All that alternative stuff such as Evening Primrose and Royal Jelly are like Jelly Beans. Does it sound mental or hormonal. No thyroid problems, regular menstruation. Anything you have been through?