What should I do with the rude,cool kids?

I just started school yesterday and on the way home I was having a fun and good 1st day,but had problems with the locker (whatever) and then on the bus these two mean girls were messing with my head and saying retarded,wild,and innapropriate crap to me and I just really couldn’t take it.I’m afraid that in the next year older people like them will just keep messing and making fun of me all because of no reason!I came back home practically crying and freaking out!I didn’t want to go to school and it was nothing like I expected it to be and I was confident and happy until they ruined it.I’ve tried talking to all my friends and my sister and they all said I should ignore them and act like they’re not there or tell them to stop and fight with words.
Is that right?
Should I do it?
Today they didn’t talk to me but they looked at me,I don’t know if that means anything or not but I don’t know…everyone says they’re the royal skaters and populars but I try not to let that get to me and when they spoke to me like that,I lost my confidence right away.But today was a better day though.:)