Amazing scientific and technological progress - Is the number of open questions actually decreasing?

From Wikipedia: Epistemology or theory of knowledge is the branch of philosophy concerned with the nature and scope (limitations) of knowledge. It addresses the questions:
* What is knowledge?
* How is knowledge acquired?
* What do people know?
* How do we know what we know?
* Why do we know what we know?

Much of the debate in this field has focused on analyzing the nature of knowledge and how it relates to similar notions such as truth, belief, and justification. It also deals with the means of production of knowledge, as well as skepticism about different knowledge claims.

http://en.wikipedia.org/wiki/Epistemology

Will quantum gravity end the need for further research in fundamental physics? Because quantum gravity can ultimately explain any natural phenomenon including dark matter and dark energy and what happened during the 10^-50 second after the big bang. What if at some point a fifth fundamental force is discovered? Or can someone rule this out for certain?

Personally, I believe in the principle that every new answer results in at least two new questions. The quest for knowledge is an infinite undertaking. Science does have limits. Even a human mind merged with a technological superintelligence would have limits. But not everyone agrees with this view. We already know almost everything, some would argue, and we are very close to closing the remaining gaps. Does this mean the number of open questions actually decreasing?