What would you give up for a chance to be happy?

I’m a lucky man. I love my wife. I love my kids. I own a home, a car, and I have retirement savings. But I am not happy. I don’t feel whatever it is from my wife that would really connect me, in spirit, to her. I want a chance for that. I want a chance to feel whole. I want it so much, that I think I would give up all that in order to try to find it—with no guarantee that I could find it.

Without judging me or offering me advice on my own particular situation (I know that’s a lot to ask), I’d like to know if you’ve ever had a choice like that. Do you know anyone who had a choice like that? What was your mood while facing and making this choice? What did you choose? How did it work out? How hard was it? What went wrong?