Should I assume the friendship is over?

I am in a dilemma about whether or not I should hold out hope on this friendship or assume it’s over. One of my very best friends from high school has just quit talking to me. I’ve texted her and messaged her on facebook asking if she’s mad at me, but there has been no response from her on either. The reason I’m thinking she’s mad is because for about 6 months her son and my daughter have had a long distance relationship. Recently my daughter ended it and is now dating someone else. She ended it because he never texted or called and I was frequently asking his mom (my friend) what was up. Usually it was a simple matter of minutes. Then one day he disappeared. When I asked what was up I was just told “he thinks he knows everything”. Well he has friends that he could’ve had deliver a message, or his mom could’ve said something to let us know where he was and what was up. He could have called via pay phone. There are any number of ways he could’ve let her know something, but he didn’t, so she assumed he wasn’t interested anymore. I mean a long distance relationship requires communication at least! Anyway I don’t know if she’s blaming me or just hasn’t responded due to unforeseen circumstances! Should I wait or consider it over?