Would you choose to do the right thing even if it meant turning many people against you?

This can refer to anything. I find I run into this situation every now and then in my life. This could mean in any type of situation such as defending someone who is always being picked on by co-workers, someone being picked on in school, defending a certain veiwpoint or for whatever reason.

Would you be willing to put your own reputation on the line to do at least what you personally feel is the right thing or do you have limits?