Have you ever made a U-turn in life?

I’m just interested in hearing people’s stories about their career/job/life in general. For example: Have you always thought that you would have a certain profession (be it doctor, scientist, teacher, etc) only to decide later on that maybe there is something else for you? I’m conflicted in my own life right now because I have always thought of myself as being a research scientist (getting my MS, PhD, and government job), but now I think (I nearly have my MS) that maybe I was wrong, and I should do something else. How has it worked out for you?