What is your process for making a very tough decision?

You have a decision that must be made. You have gone through the pros and cons a million times. Each option has many good aspects and many not so good. What is your process for making a very tough, life-changing decision? Bonus: Yours is not the only life impacted, you have a family that will be impacted by your choice as well. Neither choice will hurt your family but they will be impacted by either.

P.S. While I am asking this question for ideas to help me make a personal decision, I am not facing any Sophie’s Choice type of personal dilemma.