Solar panel efficiency?

If you have solar panels at different angles on your roof, would that lower the overall production of power? I’ve heard that if some cells are producing significantly less than the others due to partial shading or whatever reason, it acts like a sort of circuit, and a lot of energy is lost. Is this true? We’re building a solar house, and we’re just designing it now, and we want to know if we can have some panels at different angles on the roof, which would make some produce more than others at different times, but might be more aesthetically pleasing.