Can I uninstall the older versions of updates on my computer and just leave the most current one installed?

I’m cleaning house, trying to get faster response time on my computer. I’m showing like a gazzillion “security updates for windows internet Explorer…” and I don’t use Explorer. I also have 20 gazzillion Windows XP Hotfixs. I don’t know what they are. I wish someone could take a look at all the crap I have installed and tell me what I can safely uninstall….