Are some people better off not being cured?

With everyday medical cures being discovered everyday, is it better in some cases to leave it alone?
Lets take a person who was in a coma. They wake up to find everyone ever important to them is gone and they are older and their body is a wreck and they will still need to depend on services to get around.
But what if they were a violent crimminal and spent most of their lives in jail and then a cure comes a long and they are no longer a crimminal but no one on the outside can forgive them for past crimes.
Or you’ve been locked in a deep depression for years and your now 90 and the last time you remember feeling happy was when you were 20. Its like waking up from a deep sleep to find your in a different world and you were robbed of joy for years.
So in these cases, would the end justify the means. Or is it better to never know what you missed?