What is the best or most efficient antidepressant?

I’m looking into switching my medication – I currently take 20mg of Cipralex daily and it’s just not cutting it for me. I have been on a variety of different drugs for my depression/anxiety and mood, including Prozac, Remeron, and Paxil. Prozac works okay, but Remeron and Paxil caused way too much weight gain for my liking. I will be talking to my doctor about this, obviously, but I’m just curious to get people’s opinions on which antidepressants work the best. And if it helps, I am a 20 year old female with a long history of clinical depression, severe mood swings, anxiety, irritabilty, etc.