What could a person do if they are stuck in life?

This is very personal. My sister is in her 40’s, separated, has a son going to college this year and a daughter who has two children and a low-income job. My sister is unemployed with no formal education and no professional skills. My niece is in the same boat. Her “boyfriend” is out of the picture and so the children have no father and my sister is taking that role to help her daughter. My sister is stressing more than she can manage because her bills aren’t being paid, her husband lives with another woman elsewhere with an additional two children, and my sister is set back from her plans to move back to New Jersey from Florida to find a job and move on with her life. She calls me and we talk and I feel horrible that I am in no position to help her with the exception of listening to her. She cries to me and spills her guts about her aspirations and concerns, but our sisters and mother are of no condolence to her despair. Childcare is expensive, everywhere is a considerable distance to drive (it’s Florida), and of course, the job market is not strong.

If you are going to consider answering to this forum, I only ask for respect and ideas. No jokes please.

What are your ideas in finding a solution for a situation like this where a plan can be implemented and a family can get back on their feet again? I can only imagine the millions in this situation, but this is family and I have no other alternative as I am heartbroken.