Can I teach my grumpy cat to be less grumpy?

Alriiiight question #20000 of mine about my cat, Barnes.

Basically I now have a roommate that has a cat. This is a first for me, cause Barnes is so grumpy and hates other animals. Well, this other cat is a 2 year old female. She is a great cat, pretty relaxed but is still young enough to be very active and she wants to play a lot. She seems to have an adorable little crush on my older cat, Barnabus, who is about to be 11. Anyhow, I live in a one bedroom apartment and although it is very spacious for a one bedroom, the cats do encounter each other frequently. And I’ll tell you what I’m getting sick of all the hissing. My question is if there is any way I can possibly associate being unpleasant and grouchy for Barnabus with being punished (like sprayed with water)....or if it just doesn’t work that way. This other cat is very respectful so to speak of Barnes’s space…up until last week she wouldn’t even get on the couch. She never comes in my room (where he hangs out a lot), she doesn’t eat his food, drink his water, etc. She seems to have claimed the bathroom as her space which is fine cause he doesn’t go in there. But is what I’m asking just not possible? Can I get my cat to stop hissing at her and taunting her just like it were any other undesirable activity? Or does it just not work like that?