Is anything worth the energy and emotion?

When expressing disapproval of something or support for change, it’s very common to be met with claims that there are more important things to worry about. This applies to things like state-sanctioned prayer, limitations to reproductive freedom, standardized testing in schools, restrictions to freedom of speech, etc. There are always people who will claim that there are simply more important things to worry about.

Is it possible to concern ourselves with anything at all if there are always things that are more important? Is there a single issue/thing that is worthy of concern? If so, this would by definition be the most important thing to exert our energy on.

So, what is the one thing we should spend our energy and emotion on? And why are we here on Fluther instead?