How important is it to be able to live with uncertainty?

I just came across this book listing Based on the reviews on Amazon and other sites, I am not planning on reading it, though I may glance through it at the library. It appears that the book is better at stating the problem than telling how to deal with it.

It is an interesting topic and there are a lot of questions that it opens. Is there value in being able to recognize our discomfort with ambiguity? Are there times when it is okay to seek closure?

Obviously, you can’t live being uncertain of everything. Is it better to look at things from the point of view of critical thinking, whose guiding principle is “be skeptical”? This would place emphasis on evaluating evidence and determining the likelihood that something is true.

Is there danger in being too tolerant of uncertainty? I am thinking of people who seek out risky situations.

Sorry for raising so many questions, but I am having uncertainty as to how to deal with uncertainty. Feel free to provide any guidance or to raise additional questions.