What would be a good response for people who may comment that you're "over qualified" for the job?

I’ve been applying for admin assistant positions, many of which only require a HS diploma or GED, and computer skills. One that I was really interested in was working for a county attorney, but I haven’t heard from them yet.

I have a bachelors degree + 15 other college credit hours, a teaching license, a real estate license, as well as years of customer service training and experience in a variety of positions, including wireless technology and education. I worked for Edward Jones for a time, as an Office Manager. I owned my own business for 4 years. I taught in a high school diploma completion program for adults for 3 years. Most of that time was spent teaching in a county jail. I loved it.

I need a job! I need an income to supplement what my husband brings home. It doesn’t have to be $50,000 a year, and my desire for high profile, corporate ladder climbing has waned.

So, what would be a good response to someone who may say I’m over qualified for a position that only requires a high school diploma?