What are some tactics you use when playing Words With Friends?

I wonder why some people are so bad and others are out of this world amazing! I’m somewhere in the middle.

On an opening move, if I can’t hit the DW I play the shortest 2 letter, low point word as an opening, thinking it will restrict their next move. That’s one I use, but I’m not sure if that’s even a good move.

So talk to me! I have a couple of people I’m Jonesing to beat and I can’t! One of them lives here.