What kinds of issues would some states have that Kansas wouldn't also have that would be of concern in a Presidential election?

We are having a debate on another thread about the Electoral College. The main argument FOR the college is so that the entire outcome isn’t determined by the most populated portions of the country. Let’s take California v Kansas. What would California voter’s issues be that I would think are not important, and vise versa? Issues that could be affected by a national presidential election, NOT a state congress, governor or senate election.

It seems to me that individual state issues need to be addressed at the state level. The president is in charge of the well being of the entire nation, not just one part of it (present company aside.) For the most part, I think the presidents,up to now, have done a very good job governing that way, too.

To be clear, I’m asking for concrete state issues that differ from states to states and that may be addressed at the presidential level. Historical examples are welcome.