What is the latest on Covid-19 mutations, and how will this affect vaccine development?

In addition to a having a doctor in the house, I’m sure there are some here who are well-read re: C-19. I have seen a few articles on possible C-19 mutations and the health effects these new mutations could have on humans.

While I understand that this is all speculation at this point, what is the common understanding regarding virus mutation? Since viruses mutate, wouldn’t developing a vaccine be as challenging as deciding which flu strain to target each year for the flu shot? Could we develop a vaccine that works for a particular strain, only to end up with a different strain sweeping throughout the world? Could we be living with C-19 indefinitely, like we do the flu?