How many Americans will die from Covid?

We are about to hit 400,000 dead, with 4,000 dying each day.
We also are in the early days of vaccine distribution.
There are 2 mutant strains that seem especially threatening.
We are also about to have a change in Government, and how they are handling all this.
Plus, we have a lot of people who refuse to wear masks or get vaccinated. On top of that, we have people who are exhausted and worn down from the pandemic.

With all this, what is an expected endpoint?