What do you do when you have the feeling of being "lost?"?

You know the feeling: no direction, no goals, no sense of reason or purpose, no inspiration, no hope, no validity, no sense of worth.

And what to do when the things you normally do to help you cope with this feeling don’t work anymore and in fact often leave you feeling even more “empty?”

p.s.
And turning to “The Book” or any “higher power” won’t do a damn thing for me, so please don’t bother.