My cat has flipped his lid, I think. Can anyone suggest something to calm him down?

Before I go further, yes, he’s gone to the vet. I believe the phrase, “Your cat is very interesting” was used, a lot. He is losing hair, no physical ailments have been detected. He hisses at the wall and then does his nightly laps around the house. Laps are normal, other two behaviors are not so normal. The vet gave him sedatives for the night were he seems to really be freaking out, but I hate to give him drugs.

Does anyone have any “calming” suggestions for my spazz of a cat? Really…it’s quite the show, but it gets to be a bit much. I do worry about him.

Nothing big has changed in the house – things are pretty much the same. I know it’s not an environment change.