How would you determine whether to participate in biomedical/clinical research?

Would you participate to get money?
Because a loved one suffered from the disease being studied?
Because you are an advocate for research?
Because you believe in the greater good?
Because of the cost/benefit ratio?
Because the disease is awful?
Because there don’t appear to be many side effects?
Because the University sponsoring the research is well regarded?
Because it has been well publicized?

What are your thoughts about such research?
Do you trust the investigators?
Would you be afraid they weren’t telling you everything?
Would you wonder if they were secretly injecting you with some unknown/unstudied/unsafe substance or disease?
What would you ask the investigators?

What are your thoughts?