What are some long lasting dog treats?

I’m a doctoral student who is home probably 20 hours/day, and I’m basically a single “mom” to a 5 year old beagle, Roxy. She is extremely allergic to corn, epileptic, has acid reflux, and is highly destructive. Roxy’s currently tethered to my foot as the only way I can keep her from getting into trouble (attacking shoes, chewing metal, eating the carpet, etc) without just putting her in her crate.

She loves pigskin treats, but they make her smell like death, only keep her occupied for 10–20 min and they cause her to eat her own poo I’ve tried kongs/bones filled with peanut butter/kibble/etc, puzzle toys, bully sticks, and even the toughest toys are destroyed in <30 minutes. She’s ball-obsessed and will just bark at you to play fetch. Walks just give her more energy and doesn’t work at 1am in a city. She’s quiet in the yard during the day but starts playing doggy relay operator within 5 minutes at night, much to my housemates’ and neighbors’ dismay.

With all of this in mind, what are some long term (hour plus? please?) treats/activities that my dog can do indoors on her own? I’m thinking of maybe doing raw bones in her crate, but I’m afraid of upsetting her (extremely delicate) system.