For runners: do you ever feel like utter hell after not running for a few days? Why is this?

I don’t know what causes this exactly, but I physically feel terrible whenever I stop running for more than a few days (in this case, because I am nursing a stress reaction in my upper shins). I feel extremely lethargic, lazy, apathetic, slightly depressed, as if all of my muscles are atrophying. Is that what’s happening? Is there some sort of neurological explanation for this—like I’m suffering from runner’s high withdrawal?